Resihance (Regorafenib) – 40 Mg

✅ Key Benefits

• Potent anti‑angiogenic and anti‑tumor activity via multi‑kinase inhibition

• Demonstrated survival benefit in hard-to-treat metastatic colorectal cancer

• Effective in GIST and advanced liver cancer where other treatments have failed

• Convenient oral film-coated tablet in 40 mg strength for flexible dosing adjustments

• Can be combined or used sequentially as part of broader treatment protocols

🎯 How to Use

• Standard dose: 160 mg (four 40 mg tablets) once daily for 21 days, followed by 7 days off—total 28-day cycle

• If dose reduction needed, adjust in 40 mg tablet increments; lowest effective dose typically 80 mg daily

• Take at same time each day after a low‑fat meal (under 30% fat content)

• Swallow tablets whole with water; avoid grapefruit juice

• Continue until disease progression or intolerable side effects

⚠️ Precautions

• Prescription-only; contraindicated during pregnancy and breastfeeding; effective contraception required in both men and women for at least two months post‑treatment

• Monitor blood pressure regularly; hypertension is common and may require dose interruption

• Regular liver function tests necessary during first two months due to risk of serious liver injury, particularly in patients of Asian descent

• Watch for bleeding risk; avoid high-risk activities and monitor for signs of hemorrhage

• May impair wound healing; discontinue at least two weeks before elective surgery

🤕 Possible Side Effects

Common (may require monitoring or dose adjustment):

• Hand‑foot skin reaction (palmar‑plantar erythrodysesthesia)

• Fatigue, loss of appetite, weight loss

• Diarrhea, mucositis (mouth sores), hypertension, voice changes (dysphonia)

Other notable effects:

• Hair thinning or hair loss, nausea/vomiting, dizziness, headache, skin rash

Rare but serious:

• Severe liver toxicity, gastrointestinal perforation, arterial thrombosis, cardiac events, hemorrhaging

• Signs requiring immediate medical attention include jaundice, dark urine, abdominal pain, bleeding from any site, chest pain, sudden severe rash, or major blood pressure elevation

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• 📦 Discreet packaging with secure, confidential checkout

❓ Frequently Asked Questions (FAQs)

Q. What cancers does Resihance 40 mg treat?
It’s indicated for metastatic colorectal cancer, advanced GIST, and hepatocellular carcinoma when other treatments have failed.

Q. What is the standard dosing schedule?
Usually 160 mg daily for 3 weeks, followed by 1 week off, repeated until disease progression or intolerable toxicity.

Q. Can the dose be adjusted?
Yes. Dose may be reduced by 40 mg tablets at a time; lowest recommended is 80 mg daily.

Q. Can I take the medication with or without food?
Take after a light, low-fat meal to optimize absorption—avoid heavy or fatty meals and grapefruit products.

Q. What if I miss a dose?
Take it the same day if remembered, but do not take two doses in one day. If vomiting occurs, do not replace the dose—inform your doctor.