Hydrea (Hydroxyurea) – 500 Mg

✅ Key Benefits

• Helps control proliferative blood cancers like CML

• Reduces pain crises and improves blood flow in sickle cell disease

• Enhances response when combined with radiation or other chemotherapy for solid tumors

• Oral 500 mg tablet allows flexible daily dosing

• Useful in long-term disease management when standard therapies are inadequate

🎯 How to Use

• Follow prescribing physician’s instructions—dosing varies by condition and patient response

• Typical starts:

  • CML or solid tumors: 15–25 mg/kg daily, often divided once or twice daily

  • Sickle cell disease: until target blood counts and symptomatic relief achieved

• Take with water, with or without food—preferably at the same time each day

• Monitor blood counts regularly—do not self-adjust dose

• If a dose is missed, skip it if it’s close to the next dose; do not double dose and consult your healthcare provider

⚠️ Precautions

• Prescription-only; contraindicated during pregnancy or breastfeeding—causes fetal harm

• Requires frequent blood monitoring—risk of severe anemia, leukopenia, thrombocytopenia

• Bone marrow suppression may occur—watch for signs of infection, unusual bleeding, or fatigue

• Long-term use associated with rare risk of secondary malignancies or leg ulcers

• Not recommended for patients with severe renal or hepatic impairment without close oversight

🤕 Possible Side Effects

Common:

• Low blood counts—neutropenia, anemia, thrombocytopenia

• Nausea, loss of appetite, mild gastrointestinal upset

• Fatigue, dizziness, headache

Less Common:

• Skin rash, nail changes, pigmentation changes, leg ulcers (rare)

• Elevated liver enzymes or mild hepatic dysfunction

Rare but Serious:

• Severe bone marrow suppression leading to infections or bleeding

• Secondary malignancies with long-term use

• Pulmonary fibrosis, especially when combined with other drugs

If any serious symptoms—e.g. persistent fever, bruising, bleeding, severe fatigue, abdominal pain, yellowing skin—appear, stop medication and seek medical care promptly.

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❓ Frequently Asked Questions (FAQs)

Q. What conditions does Hydrea 500 mg treat?
It’s used in chronic myeloid leukemia, certain cancers (like head and neck tumors), and sickle cell disease to reduce crises and improve blood counts.

Q. How is dosing determined?
Physicians tailor the dose based on body weight and disease type; frequent blood monitoring is essential.

Q. What if I miss a dose?
Take it when you remember only if it’s not near the next scheduled dose—never double up. Consult your provider for further guidance.

Q. Are blood counts closely monitored?
Yes. Regular CBC monitoring is mandatory to adjust dosing and minimize risks like anemia or low white cells.

Q. Can it be used long-term?
Yes, with physician supervision. Long-term use may require monitoring for rare side effects like ulcers or secondary cancers.