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Combutol 1000 Mg (Ethambutol)

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Combutol 100 mg contains ethambutol hydrochloride, a bacteriostatic agent essential in first-line tuberculosis treatment. This low-dose tablet supports precision weight-based dosing, especially in pediatric patients or adults needing dose adjustments. It helps suppress Mycobacterium tuberculosis replication and prevents resistance when used alongside other standard TB drugs such as isoniazid, rifampicin, and pyrazinamide.

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Key Benefits

  • Low-dose formulation for tailored weight-based therapy

  • Improves accuracy in dosing for children or dosage adjustments in adults

  • Supports standard combination TB regimens to reduce resistance

  • Oral tablet format simplifies administration under clinical supervision

  • Ideal for early intensive phase or continuation phase of TB therapy

🎯 How to Use

  • To be used under direct physician or TB program supervision, as part of multi-drug TB therapy

  • Dosing based on body weight (typically 15–25 mg/kg/day) to match clinical protocols

  • Swallow with plenty of water; may be taken with or without food

  • Do not adjust or skip doses without doctor’s consent

  • If a dose is missed, take it when remembered unless it’s close to the next dose—do not double dose, and inform your healthcare provider

⚠️ Precautions

  • Prescription-only medication used in supervised TB treatment

  • Vision testing (baseline and periodic) is mandatory to detect possible optic nerve effects

  • Should not be used in patients with pre-existing optic neuropathy

  • Monitor liver and renal function during use, especially when combined with other anti-TB medications

  • Pyridoxine (vitamin B₆) may be co-prescribed with isoniazid to prevent neuropathy

🤕 Possible Side Effects

Common:

  • Blurred vision or difficulty distinguishing colors, mild gastrointestinal upset, decreased appetite, rash

Less Common:

  • Headache, fatigue, mild elevation of liver enzymes, tingling or numbness in hands or feet

Rare but Serious:

  • Optic neuritis—can lead to reversible or permanent vision changes if not detected early

  • Severe liver dysfunction or allergic reactions

  • Seek medical attention immediately if you experience vision changes, jaundice, persistent numbness, or severe abdominal pain

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Frequently Asked Questions (FAQs)

Q. What is Combutol 100 mg used for?
It is used as part of first-line tuberculosis combination therapy, especially for precise weight-based dosing in adult or pediatric patients.

Q. Can it be used alone?
No. Ethambutol should always be administered with other anti-TB medications—such as isoniazid, rifampicin, and pyrazinamide—for effective treatment and to prevent resistance.

Q. Why is vision monitoring required?
Due to risk of optic neuritis, baseline and ongoing visual assessment is essential, especially in prolonged or high-dose use.

Q. Is pyridoxine necessary?
Pyridoxine is often co-prescribed with isoniazid-containing regimens to reduce risk of peripheral neuropathy, particularly when combined with ethambutol.

Q. What if a dose is missed?
Take it as soon as remembered unless it’s close to your next dose. Never double up. Notify your healthcare provider.

Unit

120 Tablets, 150 Tablets, 300 Tablets, 90 Tablets

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