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Combutol 600 Mg (Ethambutol)

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Combutol 600 mg is an oral ethambutol hydrochloride tablet used in combination with other first-line anti‑tuberculosis drugs (such as isoniazid, rifampicin, and pyrazinamide) to effectively manage pulmonary and extrapulmonary TB. This high-dose tablet simplifies dosing for adult patients and aligns with weight-based regimen protocols

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Key Benefits

  • High-strength 600 mg dosage reduces pill burden in adult TB therapy

  • Enhances efficacy of multi-drug regimens and helps prevent resistance

  • Oral formulation that aligns with standard WHO or national TB guidelines

  • Simplifies adherence and dosing consistency in intensive treatment phases

  • Suitable for adults with confirmed TB under clinical supervision

🎯 How to Use

  • Use only under physician or DOTS program supervision as part of standard anti-TB regimens

  • Dosage is weight-based; typically 15–25 mg/kg once daily—must follow national treatment protocols

  • Swallow tablet with water; may be taken with or without food

  • Follow prescribed schedule carefully; do not share or alter dosing without doctor’s advice

  • If you miss a dose, take it when remembered unless it’s near the next dose; do not double up and inform your healthcare provider

⚠️ Precautions

  • Prescription-only; intended strictly for use under a supervised TB treatment program

  • Baseline and periodic vision testing required—elevated risk of optic neuritis, especially at higher doses or extended use

  • Contraindicated in patients with known optic nerve disorders

  • Monitor liver and kidney function regularly when combined with other anti-TB medications

  • Vitamin B₆ (pyridoxine) may be co-prescribed to reduce risk of isoniazid-related neuropathy in multi-drug regimens

🤕 Possible Side Effects

Common:

  • Blurred vision, difficulty distinguishing colors, gastrointestinal discomfort, decreased appetite, rash

Less Common:

  • Headache, fatigue, elevated liver enzymes, numbness or tingling in hands/feet

Rare but Serious:

  • Optic neuritis leading to potential vision impairment or loss

  • Severe hepatitis or allergic reactions

  • Seek medical attention immediately if experiencing vision changes, jaundice, persistent numbness, or severe abdominal pain

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Frequently Asked Questions (FAQs)

Q. What is Combutol 600 mg used for?
It’s used in adult TB patients as part of standard multi-drug treatment regimens to improve adherence and prevent drug resistance.

Q. Can it be taken alone?
No. Combutol 600 mg should always be used with other anti-TB medications per established treatment protocols.

Q. How is vision monitored?
Regular visual acuity testing is essential during therapy due to the risk of optic neuritis, particularly at higher doses.

Q. Why is pyridoxine recommended?
Vitamin B₆ (pyridoxine) is often added to isoniazid-containing regimens to reduce the risk of peripheral neuropathy.

Q. What if I miss a dose?
Take it as soon as remembered unless it’s close to the next scheduled dose. Do not double up on doses and notify your healthcare provider.

Unit

120 Tablets, 150 Tablets, 300 Tablets, 90 Tablets

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