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Combutol 400 Mg (Ethambutol)

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Combutol 400 mg contains ethambutol hydrochloride, a first-line bacteriostatic medication crucial in tuberculosis treatment regimens. It works by suppressing Mycobacterium tuberculosis growth and helping prevent the development of drug resistance when combined with other anti-TB drugs such as isoniazid, rifampicin, and pyrazinamide.

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Key Benefits

  • High-strength 400 mg dosing simplifies daily TB therapy

  • Enhances adherence by reducing pill burden in combination regimens

  • Helps prevent drug-resistant TB strains in multi-drug therapy

  • Oral tablet formulation supports standard WHO or national TB protocols

  • Suitable for adults and weight-based dosing as directed by clinicians

🎯 How to Use

  • Administer under medical supervision as part of a multi-drug TB regimen

  • Follow weight-based dosing per clinical guidelines (typically 15–25 mg/kg once daily)

  • Swallow with water; may be taken with or without food

  • Strict adherence is critical—never change or skip doses without medical advice

  • If a dose is missed, take it once remembered unless close to the next dose; do not double up, and inform your healthcare provider

⚠️ Precautions

  • Prescription-only medication, used only under supervision for confirmed TB

  • Baseline and periodic vision assessments are mandatory due to optic neuritis risk

  • Avoid use in individuals with pre-existing optic nerve disorders

  • Monitor liver and kidney function, particularly when co-administered with other anti-TB medications

  • Vitamin B₆ (pyridoxine) may be added if isoniazid is part of the regimen to prevent neuropathy

🤕 Possible Side Effects

Common:

  • Blurred vision or difficulty distinguishing colors, nausea, abdominal discomfort, rash

Less Common:

  • Headache, fatigue, elevated liver enzymes, numbness or tingling in extremities

Rare but Serious:

  • Optic neuritis, potentially resulting in reversible or permanent vision loss

  • Severe hepatitis or allergic reaction

  • Seek medical care immediately for sudden vision changes, persistent jaundice, numbness, or severe abdominal symptoms

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Frequently Asked Questions (FAQs)

Q. What is Combutol 400 mg used for?
It is used as part of standard anti-TB combination therapy to treat pulmonary and extrapulmonary tuberculosis while preventing resistance.

Q. Can it be taken alone?
No. Combutol should always be used in combination with other TB medications for effective treatment following established guidelines.

Q. How is vision monitored?
Regular visual acuity testing is essential due to the risk of optic neuritis, especially with higher-dose or prolonged use.

Q. Why is pyridoxine recommended?
Vitamin B₆ is often co-prescribed with isoniazid-containing regimens to reduce the risk of neuropathy associated with treatment.

Q. What if I miss a dose?
Take as soon as you remember if it’s not near the next dose. Do not double up. Notify your healthcare provider for further guidance.

Unit

120 Tablets, 150 Tablets, 300 Tablets, 90 Tablets

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