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Spexib (Ceritinib) – 150 Mg

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Spexib 150 mg is an oral capsule containing ceritinib, a potent ALK (anaplastic lymphoma kinase) inhibitor designed for the treatment of ALK‑positive advanced or metastatic non‑small cell lung cancer (NSCLC). It’s effective for patients who have failed or cannot tolerate crizotinib, offering improved control over certain resistant ALK mutations. Spexib targets tumor-driving pathways, helping slow progression and extending survival in molecularly defined patient populations.

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Key Benefits

  • Active in ALK‑positive NSCLC, including those with crizotinib resistance

  • Powerful oral targeted therapy—capsule format enables flexibility and dose adjustments

  • Penetrates central nervous system—may control brain metastases in responsive patients

  • Used in first-line or later-line settings depending on mutation profile and prior treatment

  • Precision treatment tailored to specific ALK-driven lung cancers

🎯 How to Use

  • Standard dose: one 150 mg capsule taken with food (low-fat meal) once daily

  • Continue treatment until disease progression or unacceptable toxicity

  • Dose modifications may be needed for liver enzyme elevation or gastrointestinal side effects

  • Swallow capsules whole—do not crush or chew

  • Close monitoring by oncology team (labs, imaging, symptoms) is essential

⚠️ Precautions

  • Prescription-only; for confirmed ALK‑positive NSCLC patients only

  • Monitor liver function regularly; ceritinib may cause hepatotoxicity

  • Watch for QT interval prolongation—ECG monitoring advised in high-risk patients

  • May cause gastrointestinal intolerance—ensure proper hydration and dose spacing

  • Not suitable during pregnancy; effective contraception should be maintained during and after treatment

🤕 Possible Side Effects

Common:

  • Diarrhea, nausea, vomiting, abdominal pain

  • Elevated liver enzymes, fatigue, decreased appetite, weight changes

Less Common:

  • Headache, dizziness, rash, elevated blood sugar or cholesterol, muscle pain

Rare but Serious:

  • Hepatotoxicity, QT prolongation, severe gastrointestinal toxicity, interstitial lung disease, pancreatitis

  • Discontinue and seek medical care for symptoms like yellowing skin/eyes, irregular heartbeat, extreme abdominal pain, or severe breathing issues

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Frequently Asked Questions (FAQs)

Q. Who should take Spexib 150 mg?
Patients with advanced ALK‑positive non‑small cell lung cancer, including those who are treatment-naïve or crizotinib-resistant.

Q. How is Spexib dosing structured?
One 150 mg capsule daily with food; continue long-term per oncology guidance, with dose adjustments if needed.

Q. Can I take it without food?
No—it must be taken with a low‑fat meal to improve absorption and minimize digestive side effects.

Q. What if I miss a dose?
Take it as soon as remembered—unless it’s near the next scheduled dose. Never take two in one day.

Q. How are side effects managed?
Supportive care, dose reduction, or treatment interruption may be required. Regular monitoring ensures safe continued use.

Unit

10 Capsule/s, 20 Capsule/s, 30 Capsule/s

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